Advanced Daily Defense Serum
NEW
NEW
NEW
Advanced Daily Defense Serum
Skin type: All Skin Types
A daily antioxidant serum designed to visibly transform stressed sensitive skin, for stronger skin against daily stressors
- IMPROVE RADIANCE, PORES & FINE LINES: Formulated with Triple Hyaluronic Acid to hydrate and smooth the skin, and Niacinamide to help minimize the appearance of pores and enhance radiance
- POWERFUL ANTIOXIDANT COMPLEX: With Gallic‑AOX Power™, a complex of Gallic Acid and Vitamin E helps defend against oxidative stress
- DESIGNED FOR SENSITIVE SKIN: This powerful antioxidant serum is suitable for even the most sensitive skin, with a hypoallergenic, fragrance free and non-comedogenic formula
- DERMATOLOGIST RECOMMENDED FOR SENSITIVE SKIN
- EFFECTIVE AM/PM ROUTINE: Pair this AM serum with CETAPHIL Repair & Renew Serum overnight to help visibly improve the overall appearance of sensitive skin in 2 weeks(1) In-Use test (clinical grading, Asian and Caucasian panel): significant improvement in overall skin quality (sum of 9 graded scores: pores appearance, fine lines, scars, skin visible redness, pigmentation, dullness, laxity, oiliness and dryness) by 6% after 14 days, by 17% after 28 days and by 17% after 56 days.
FEATURES
Start your day with CETAPHIL Advanced Defense Serum to help defend your skin against day-to-day stress. Daily external stressors can impact the skin's natural repair and renewal process, which can lead to dryness, visible redness and breakouts. This AM face serum is designed to help strengthen sensitive skin against daily stressors for more radiant-looking skin. It's powered by Gallic-AOX , a powerful antioxidant complex of Gallic Acid and Vitamin E that boosts sensitive skin's defense against oxidative stress. It's also formulated with Triple Hyaluronic Acid to deeply hydrate and smooth skin, and Niacinamide to help minimize the appearance of pores and enhance radiance. This hypoallergenic and fragrance-free formula is suitable for even the most sensitive skin, and it won't clog pores. Pair with CETAPHIL Repair & Renew Serum overnight to help visibly improve the overall quality of stressed sensitive skin in 2 weeks(1).
THE ROUTINE
%20DFC%2016oz%20-%20Front%20(1).png?sw=450&sh=450&sm=fit&q=85 "Daily Facial Cleanser")
.PNG?sw=450&sh=450&sm=fit&q=85 "Rich Hydrating Cream")
FEATURED INGREDIENTS
GALLIC ACID AND VITAMIN E (GALLIC AOX POWER), HYALURONIC ACID, NIACINIMIDE
ALL INGREDIENTS
WATER, BUTYLENE GLYCOL, PEG/PPG-8/3 LAURATE, PENTYLENE GLYCOL, POLYGLYCERYL-4 CAPRATE, 1,2-HEXANEDIOL, NIACINAMIDE, EPIGALLOCATECHIN GALLATYL GLUCOSIDE, HYDROLYZED HYALURONIC ACID, ALLANTOIN, TOCOPHERYL ACETATE, AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER, SODIUM HYALURONATE, TOCOPHEROL, SODIUM GLUCONATE, CITRIC ACID
Find out more about our ingredients
Glycerin
Glycerin is a naturally occurring compound. It is a water-soluble emollient that softens and smooths skin. It also produces long-lasting moisturization by attracting water into the skin and helping to retain skin moisture, leaving it appearing healthy and youthful.
Niacinamide
Niacinamide or vitamin B3 is an essential vitamin for the skin with both antioxidants and hydrating properties. It locks in moisture effectively.
Tocopherol
Tocopherol or vitamin E has an antioxidant effect that helps protect the skin from surface free radical damage. It also soothes skin with a hydrating effect.
Hyaluronic Acid
Hyaluronic acid occurs naturally within the skin and gives skin natural plumpness and a silky-smooth texture. With age, natural hyaluronic acid decreases. Hyaluronic acid can boost skin elasticity and impressively retain moisture.
Find your own routine with our new AI Skin Analysis tool
Reviews
Rated 4 out of
5
by
AmandaL from
Your skin will thank you later
I am SO happy to have discovered this daily serum (and my wallet is probably happy as well)! This is an amazing option for anyone wanting to improve their skincare routine without breaking the bank. I tend to get very oily skin by the end of the day and this serum has helped control the greasiness while simultaneously making it look plumper and healthier. This formula contains a lot of antioxidants and anti inflammatory ingredients that work together to reduce redness, inflammation, dark spots, and damage caused by environmental factors. I’ve noticed a huge improvement in skin tone and texture as well as foundation longevity and oil control
Date published: 2026-02-21
Rated 4 out of
5
by
MichelleF from
Advanced daily defense serum
This is the AM serum. This serum helps advance my daily defense from everyday stressors. I like the application, the dropper gives me the exact amount of product I need for each use. One bottle will last a good month. It helps my skin look and feel more radiant. Helps my skin’s barrier get stronger and visibly improves pores & fine lines. With incredible ingredients like vitamin E & Gallic Acid it’s great for sensitive skin, helps with hydration & daily pollution. It’s a high quality serum made with ingredients that will helps with daily maintenance. Like ingredients like triple Hyaluronic Acid & Niacinamide. It is fragrance-free, and made from high quality ingredients.
Date published: 2026-03-07
Rated 5 out of
5
by
MayS from
Love this morning serum
I’ve been using the Cetaphil AM serum for the past month and I absolutely love it! I apply it after washing my face in the morning, and it always feels so smooth on my skin. It leaves my skin super moisturized without being sticky which I really appreciate. I also love the glass bottle and the convenient applicator it comes with. Another big plus is that it’s fragrance free, which I always appreciate in skincare. I think the value for this product is great it’s not expensive and you get a decent amount of product that can last for a while.
So far, I’ve seen great results and I’m definitely going to keep using it.
Date published: 2026-03-01