Advanced Daily Defense Serum
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NEW
NEW
Advanced Daily Defense Serum
Skin type: All Skin Types
A daily antioxidant serum designed to visibly transform stressed sensitive skin, for stronger skin against daily stressors
- IMPROVE RADIANCE, PORES & FINE LINES: Formulated with Triple Hyaluronic Acid to hydrate and smooth the skin, and Niacinamide to help minimize the appearance of pores and enhance radiance
- POWERFUL ANTIOXIDANT COMPLEX: With Gallic‑AOX Power™, a complex of Gallic Acid and Vitamin E helps defend against oxidative stress
- DESIGNED FOR SENSITIVE SKIN: This powerful antioxidant serum is suitable for even the most sensitive skin, with a hypoallergenic, fragrance free and non-comedogenic formula
- DERMATOLOGIST RECOMMENDED FOR SENSITIVE SKIN
- EFFECTIVE AM/PM ROUTINE: Pair this AM serum with CETAPHIL Repair & Renew Serum overnight to help visibly improve the overall appearance of sensitive skin in 2 weeks(1) In-Use test (clinical grading, Asian and Caucasian panel): significant improvement in overall skin quality (sum of 9 graded scores: pores appearance, fine lines, scars, skin visible redness, pigmentation, dullness, laxity, oiliness and dryness) by 6% after 14 days, by 17% after 28 days and by 17% after 56 days.
FEATURES
Start your day with CETAPHIL Advanced Defense Serum to help defend your skin against day-to-day stress. Daily external stressors can impact the skin's natural repair and renewal process, which can lead to dryness, visible redness and breakouts. This AM face serum is designed to help strengthen sensitive skin against daily stressors for more radiant-looking skin. It's powered by Gallic-AOX , a powerful antioxidant complex of Gallic Acid and Vitamin E that boosts sensitive skin's defense against oxidative stress. It's also formulated with Triple Hyaluronic Acid to deeply hydrate and smooth skin, and Niacinamide to help minimize the appearance of pores and enhance radiance. This hypoallergenic and fragrance-free formula is suitable for even the most sensitive skin, and it won't clog pores. Pair with CETAPHIL Repair & Renew Serum overnight to help visibly improve the overall quality of stressed sensitive skin in 2 weeks(1).
THE ROUTINE
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FEATURED INGREDIENTS
GALLIC ACID AND VITAMIN E (GALLIC AOX POWER), HYALURONIC ACID, NIACINIMIDE
ALL INGREDIENTS
WATER, BUTYLENE GLYCOL, PEG/PPG-8/3 LAURATE, PENTYLENE GLYCOL, POLYGLYCERYL-4 CAPRATE, 1,2-HEXANEDIOL, NIACINAMIDE, EPIGALLOCATECHIN GALLATYL GLUCOSIDE, HYDROLYZED HYALURONIC ACID, ALLANTOIN, TOCOPHERYL ACETATE, AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER, SODIUM HYALURONATE, TOCOPHEROL, SODIUM GLUCONATE, CITRIC ACID
Find out more about our ingredients
Glycerin
Glycerin is a naturally occurring compound. It is a water-soluble emollient that softens and smooths skin. It also produces long-lasting moisturization by attracting water into the skin and helping to retain skin moisture, leaving it appearing healthy and youthful.
Niacinamide
Niacinamide or vitamin B3 is an essential vitamin for the skin with both antioxidants and hydrating properties. It locks in moisture effectively.
Tocopherol
Tocopherol or vitamin E has an antioxidant effect that helps protect the skin from surface free radical damage. It also soothes skin with a hydrating effect.
Hyaluronic Acid
Hyaluronic acid occurs naturally within the skin and gives skin natural plumpness and a silky-smooth texture. With age, natural hyaluronic acid decreases. Hyaluronic acid can boost skin elasticity and impressively retain moisture.
Find your own routine with our new AI Skin Analysis tool
FAQs
This serum is designed to help defend the skin from environmental stressors like pollution while also hydrating and brightening the complexion.
Apply every morning to cleansed skin before your moisturizer. Use one or two pumps and smooth over the face and neck.
While it is formulated for the face and neck, it can be used on other areas if desired, though it is optimized for facial skin.
Yes, it was specifically designed to for sensitive skin.
It is available at Walmart, Amazon, HEB, Meijer and Ulta.
The serum is primarily for morning use, for nighttime we recommend CETAPHIL Repair & Renew Serum to visibly improve the quality of sensitive skin.
Some results can be seen as early as the first use with full effect after one month of continuous use.
Yes, it is suitable for all skin types, including sensitive and acne-prone skin.
It is suitable for adults of all ages looking to protect and hydrate their skin.
Reviews
Rated 4 out of
5
by
AmandaL from
Your skin will thank you later
I am SO happy to have discovered this daily serum (and my wallet is probably happy as well)! This is an amazing option for anyone wanting to improve their skincare routine without breaking the bank. I tend to get very oily skin by the end of the day and this serum has helped control the greasiness while simultaneously making it look plumper and healthier. This formula contains a lot of antioxidants and anti inflammatory ingredients that work together to reduce redness, inflammation, dark spots, and damage caused by environmental factors. I’ve noticed a huge improvement in skin tone and texture as well as foundation longevity and oil control
Date published: 2026-02-21
Rated 5 out of
5
by
MelissaB from
Good serum for fine lines
I am thankful that I received Cetaphil’s Cetaphil Daily Defense AM Serum for free to review from Cetaphil and Influenster.
I have been using it daily. I shake it then apply it to my clean face right after my morning shower. I have noticed some change in my fine lines between my eyes so I will continue to use this. Before my wrinkle area looked very dry. It is more hydrated, plump, and a little less noticeable.
This serum has vitamin E and Gallic Acid for a stronger skin barrier against daily stressors. That is just what I needed.
Date published: 2026-02-19
Rated 5 out of
5
by
SashaK from
Perfect Morning Serum!
Cetaphil Daily Defense AM Serum with Vitamin E & Gallic Acid really improved my skin! This lightweight serum works to protect stressed sensitive skin against daily stressors. The formula has 3 molecular weights of hyaluronic acid that penetrates into the skin’s surface to hydrate the skin. After using this product on a daily basis my skin feels smoother, looks radiant, and reduces pores. Very lightweight and absorbs into my skin. Perfect for morning routine. I highly recommend it to everyone!
Date published: 2026-03-12